Med OS and PFS by ARM w/ or w/o Dose Reduction
Arm A
Arm C
No Reduction (n=106)
Reduction (n=134)
No Reduction (n=128)
Reduction (n=77)
OS (mos)
12.9
13.6
9.2
10.1
PFS (mos)
7.3
7.4
2.0
3.6
Hazard Ratios for Reduction versus No Reduction (HR < 1 favors dose reduction)
Arm A
Arm C
HR
P
HR
P
OS
.82
.17
.85
.30
PFS
.81
.14
.65
.0070