Median Survival (months) (95% CI)

Pain Response No Pain Response p-Value QOL Response No QOL Response p-Value

All Pts 18.2 (16–21) 12.0 (11–14) < 0.001 18.2 (16–21) 17.1 (16–19) 0.35
D3+ P 21.1 (17–24) 12.7 (10–15) < 0.001 21.8 (17–24) 17.3 (16–20) 0.16
D1+ P 17.4 (15–19) 12.4 (10–16) 0.24 17.1 (14–19) 17.7 (15–20) 0.65
M+ P 17.1 (13–24) 11.9 (10–14) 0.037 14.4 (12–23) 16.7 (14–20) 0.92