Comparison of Placebo vs MNTX Efficacy (%)
| Time to values |
Placebo (n=42) |
MNTX(n=37) (0.15 mg/kg) |
p-Value |
MNTX(n=45) (0.30 mg/kg) |
p-Value |
|
| Rescue free laxation within 4 hours (301) |
16.7 |
59.5 |
0.0001** |
55.6 |
0.0003** |
| Laxation within 4 hours (302) |
14.6a |
51.4 |
0.0007* |
|
|
| At least 2 laxations within 4 hours over the first 4 doses (302) |
7.3a |
59.5 |
<0.0001* |
|
|
| Rescue free laxation within 24 hours (301) |
28.6 |
67.6 |
0.0007* |
62.2 |
0.0025* |
|
* Fishers exact test,
** Cochran-Mantel-Haenszel,
*** log rank; MNTX = methylnaltrexone;
a n=41