n MST 1-ysr HR (95%CI) 1-sided p-value 5-FU 234 10.8M 44.0% - - CP 236 12.3M 52.5% 0.85 (0.70–1.04) 0.055 (superiority) S-1 234 11.4M 47.9% 0.83 (0.68–1.01) <0.001 (non-inferiority) 0.034 (superiority)