Endpoint Control N=347 B 7.5mg/kgN=345 B 15mg/kgN=351 PFS general Hazard ratio (95%CI) 0.75(0.62,0.90)P=0.002 0.82(0.68,0.98)P=0.03 Median PFS general (mos) 6.1 6.7 6.5 PFS censoring for NPT Hazard ratio (95%CI) 0.70(0.58,0.85) P=0.0004 0.78(0.64,0.95) P=0.0125 Response rate (%) 20 34 30 Response duration (mos) 4.7 6.1 6.1 Grade 3 AEs (%) 75 76 81 Grade 3 hypertension (%) 2 6 9 Grade 3 haemoptysis (%) <1 1.5 <1 AEs leading to death (%) 4 4 5