Journal of Clinical Oncology, 2004 ASCO Annual Meeting Proceedings (Post-Meeting Edition).
Vol 22, No 14S (July 15 Supplement), 2004: 1545
© 2004 American Society of Clinical Oncology

This Article Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Download to citation manager Rights & Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Abdulkarim, B. S. Articles by Raymond, E. Search for Related Content PubMed Articles by Abdulkarim, B. S. Articles by Raymond, E.

Abstract

Baseline pathological and radiological assessment of tumor angiogenesis predicts survival in patients with oligodendrogliomas

IGR, Villejuif, France; Shering-Plough, Levalois-Perret, France; Hopital Kremlin Bicetre, Kremlin Bicetre, France; Hopital Ste Anne, Paris, France

1545

Background. Malignant transformation of oligodendrogliomas (ODG) is associated with increased angiogenesis (endothelial hyperplasia, vascular proliferation of leaking vessels and tumor necrosis). Our aim was to evaluate the prognostic value of tumor angiogenesis assessed by pathological and radiological examinations on progression-free (PFS) and overall survival (OS) in patient (pts) with ODG. Methods.All pts with ODG consecutively treated in our Institution from 1994–2000. Pathological sections were re-evaluated to confirm the diagnosis of ODs and to assess the degree of nuclear atypia, mitosis, endothelial hyperplasia, and necrosis. CT-scan and/or MRI images were re-analyzed to assess contrast enhancement and necrosis. A multivariate analysis was performed including baseline demographic data, histological and radiological factors associated with tumor angiogenesis and treatment. Results. 134 pts with histologically confirmed low grade (WHO grade II, n=49) and anaplastic ODG (WHO grade III, n=85) were analyzed. Univariate analysis showed that prognostic factors associated with better PFS and OS were age <55 (p<0.0001), ODG revealed by seizure (p<0.0001), lack of endothelial hyperplasia (p<0.001), lack of contrast enhancement (p=0.02), and lack of histological/radiological evidence of tumor necrosis (p<0.0001). Multivariate analysis identified necrosis, endothelial hyperplasia and/or contrast enhancement, age, and seizures as independent bad-prognostic factors for OS. This enabled us to defined three pts groups (low, intermediate, and high risk ODG) according to NEVA score using the more robust parameters (necrosis, epilepsy, vessel and age). Conclusion. Endothelial hyperplasia, contrast enhancement, and necrosis that reflect a mutli-step development of tumor angiogenesis are independent factors of bad prognosis in pts with ODG.

No significant financial relationships to disclose.

Abstract presentation from the 2004 ASCO Annual Meeting