Journal of Clinical Oncology, 2005 ASCO Annual Meeting Proceedings.
Vol 23, No 16S (June 1 Supplement), 2005: 10
© 2005 American Society of Clinical Oncology

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Abstract

Dietary fat reduction in postmenopausal women with primary breast cancer: Phase III Women’s Intervention Nutrition Study (WINS)

Los Angeles Biomed Research Institute, Torrance, CA; Beth Israel Deaconess Hosp, Boston, MA; Univ of CA, Los Angeles, CA; Univ of Arizona, Tucson, AZ; Univ of Hawaii, Manoa, HI; Park Nicollet Institute, Minneapolis, MN; John Wayne Cancer Institute, Los Angeles, CA; Kaiser Permanente Ctr for Health Research, Portland, OR; The Institute for Cancer Prevention, New York, NY

10

Background: Despite preclinical and observational studies suggesting benefit, dietary fat influence on breast cancer outcomes has been controversial. Methods: We conducted a randomized trial to test whether an intensive dietary intervention designed to reduce dietary fat intake was effective in influencing relapse-free survival in postmenopausal women with primary breast cancer. A total of 2,437 women with early stage resected breast cancer, 48–79 years old, were randomized within 365 days from surgery in a 40:60 ratio to dietary intervention or control groups at 37 U.S. sites. All received standard breast cancer management: mastectomy or lumpectomy plus radiation; tamoxifen for ER positive, protocol-defined chemotherapy for ER negative and optional chemotherapy for ER positive cases. The dietary intervention included eight bi-weekly individual counseling sessions conducted by centrally trained nutritionists who provided ongoing contacts throughout. Results: Patient characteristics and recurrence risk factors were balanced. Dietary fat intake reduction was greater in the dietary group (fat gram intake/day at 12 months, 33.3 ± 16.7, mean ± standard deviation (SD) versus 51.3 ± 24.4 in controls, respectively, p<0.001). After 60 months median follow-up, the 277 reported relapse events are outlined below by treatment group and receptor status. Conclusion: Life-style intervention resulting in dietary fat intake reduction may improve the relapse-free survival of postmenopausal breast cancer patients.

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Abstract presentation from the 2005 ASCO Annual Meeting