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Journal of Clinical Oncology, 2005 ASCO Annual Meeting Proceedings.
Vol 23, No 16S (June 1 Supplement), 2005: 825
© 2005 American Society of Clinical Oncology
Young age is not always an adverse prognostic factor in breast cancer
M. A. Seoud,
M. Khalil,
N. El- Saghir,
Z. Salem,
M. Charafeddine,
J. Abbas,
M. Sidani and
A. Shamseddine
American Univ of Beirut, Beirut, Lebanon
825
Background: This is a survival analysis of Lebanese women with breast cancer treated at AUBMC between 1990 and 2001 Methods: Charts of all breast cancer patients (pts) treated at AUBMC between 1990 and 2001 were retrospectively reviewed. Chart information was completed by telephone interviews. Patients were divided into three groups: Below 35 years (group 1), 35–50 years (Group 2), and above 50 years (Group 3). Data was analyzed using SPSS, Chi-square, Cox regression analysis, and Kaplan Meier. p<0.05 was considered as significant. Results: There were a total of 1320 pts of whom 823 had a complete follow up. Mean age at presentation 50.8 ± 12.2 years. Only 56% of the patients were postmenopausal. Mean follow-up time was 42 ± 35 months. Age distribution was as follows: 108 pts (8.1%) in group 1, 526 pts (39.9%) in group 2 and 686 pts (52%) in group 3. Distribution of the stage at presentation among these groups was not statistically different p=0.653. Hormone receptor status (ER and/or PR) was not statistically different between the 3 groups with p value of 0.259. Group 1: 67.9%, group 2: 63%, and group 3: 68.7% had positive receptors. 73.6% of Group 1 pts received chemotherapy compared to 70.6% and 50.8% in groups 2 and 3 respectively (p<0.001), whereas 77.4% of hormone positive group 3 pts received hormonal therapy compared to 63.2% and 69% of groups 1 and 2 respectively (p<0.001). Five-year survival for hormone positive patients was 86.4% compared to only 69.6% for hormone negative pts (p<0.001). Kaplan-Meier 5-year projected survival by stage was not influenced by age. It was 72.5%, 79% and 80% in groups 1, 2 and 3 respectively. (p= 0.15). Univariate analysis showed that higher number of positive lymph nodes (LNs), negative hormonal receptors, higher grade, and bigger tumor size were predictors of death irrespective of the age group, and adjuvant treatment. Multivariate analysis showed that only the number of positive LNs, and hormonal status were predictors of death which was also independent of the age group. Conclusions: In our population, the survival of young patients with breast cancer is similar to older patients. This may be related to a higher percentage of receptor positive patients
No significant financial relationships to disclose.
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