Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings (Post-Meeting Edition).
Vol 24, No 18S (June 20 Supplement), 2006: 10612
© 2006 American Society of Clinical Oncology

This Article Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Download to citation manager Rights & Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Maarraoui, A. M. Articles by Attia, N. M. Search for Related Content PubMed Articles by Maarraoui, A. M. Articles by Attia, N. M.

Abstract

Breast cancer in United Arab Emirates: Younger patients and more aggressive histology

Mafraq Hospital, Abu Dhabi, United Arab Emirates; Gulf Medical College, Ajman, United Arab Emirates; Ajman Medical College, Ajman, United Arab Emirates; ADIS, Abu Dhabi, United Arab Emirates; RPS, Abu Dhabi, United Arab Emirates

10612

Background: Mafraq hospital is the largest tertiary hospital in UAE. We tested the hypothesis that breast cancer patients in UAE present at a younger age and with more aggressive tumor histology Methods: This is a retrospective study on breast cancer cases seen at Mafraq hospital between 1/00 and 12/05. Intent to treat analysis was used. Total of 372 patients were seen, 48 patients (12.9%) were UAE citizens and 324(87.1%) were non-citizens, 370 females and 2 males. We categorized patients according to their age at time of initial presentation, menopausal status, TNM stage, tumor grade, lymphatic and vascular invasion, ER, PR, Her-2 neu and P53 status. Mode of surgery is also reported. Results: Mean patients age at time of initial presentation is 48 years. 230 (62%) of patients were pre-menopausal and 140 (38%) were post-menopausal. Tumor stages at initial presentation were as follows, stage 0: 7 patients (0.2%), stage I:59 patients (15.9 %), stage II: 180 patients (48.6%), stage III: 71 patients (19.2%) and stage IV: 53 patients (14.3%). Staging was not completed in 2 patients as they followed elesewhere. Vascular invasion was reported in 118 case, 58 (49.2%) were positive and 60 (50.8%) were negative. Lymphatic vessel invasion was reported in 106 case, 84 (79.2%) were positive and 22 (20.8%) were negative. Tumor grades were reported in 265 case and were as follows GI: 33 (12.5%), GII: 121 (45.6%), GIII: 109 (41.1%) and G IV: 2 (0.8%). Tumor hormonal status was reported in 270 case and were as follows: ER+ and PR+ in 94 case (34.8 %), ER+ and PR- in 31 case (11.5%), ER– and PR+ in 25 case (9.3%) and ER– and PR– in 120 case (44.3%). ER and PR were unknown in 102 case. Her2 neu studies were performed in 157 case. Out of those 77 (49%) were positive and 80 (51%) were negative. P53 mutation was studied in 132 patients 33 (25%) were P53 positive and 99 (75%) were P53 negative. 346 patient underwent surgery, 233 patient had modified radical mastectomy and 113 (32.7%) had breast conserving surgery. Conclusions: Breast cancer in UAE tends to occur at a younger age compared to western countries. The majority of our patients are pre-menopausal. Tumors have more aggressive histology and biology. Most tumors show vascular and lymphatic invasion. P53 and Her-2 neu over-expression is relatively high.

No significant financial relationships to disclose.