Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings (Post-Meeting Edition).
Vol 25, No 18S (June 20 Supplement), 2007: 16070
© 2007 American Society of Clinical Oncology

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Abstract

Ovarian adenocarcinoma in teenagers and young adults: A clinical challenge

Instituto Oncologico Henry Moore, Buenos Aires, Argentina

16070

Background: Ovarian cancer (OC) appears at an average age of 63, and is uncommon in younger patients (pt), with only about 5% being diagnosed below 30 years of age. The aim of this study is to analyze the onset and prognosis of ovarian adenocarcinoma (OA) in teenagers and young adults treated at the IOHM. Methods: From Oct 87 through Nov 06, 467 pt were diagnosed with OC. Twenty six pt (5,35%) were young adults or teenagers. Ten out of the 26 pt had OA, while the other histological types were as follows: 7 pt Germ cell tumors- 5 pt Borderline - 2 pt stromal tumors - 1 pt neuroendocrine - 1 pt undifferentiated. Characteristics of the Population: Median age: 22 years (range 15–29). Symptomatology: 6 pt presented pain and pelvic tumor, two pt malignant ascites, and one skin nodules. Stages: I (4 pt), III (3 pt), IV (2pt), Not registered: 1 pt. Histological Subtype: Serous: 2pt, Endometroid: 1pt, Mucinous: 4 pt. Non-specified adenocarcinoma: 3 pt; Histological Grade: 1: 4pt; 2: 2pt, 3: 3pt. Not registered: 1 pt. Results: All pt were surgically treated (optimal surgical cytoreduction: 5/ 9). All pt received first line chemotherapy based on a Platinum combination. The average follow up time was 58 months (range: 4–162). Five pt are still alive (Median Duration of Survival 78 months (range 12–162) and four of them are free of the disease (Stage I: 3pt and Stage III: 1pt). Conclusions: 1- The OA in teenagers and young adults is uncommon and only stands for 2% of the total ovarian tumors (10/467). 2- In contrast with its adult counterpart, the ascites as an initial symptom was only present in two of our cases. 3-Three out of four stage I pt and one stage III pt are still alive and disease free after 60 months.

No significant financial relationships to disclose.